Chlamydial protease-like activity factor targets SLC7A11 for degradation to induce ferroptosis and facilitate progeny releases.

PLoS Pathog · 2025 · PMC12011302 · PMID 40198689

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Pharmacological inhibition of ferroptosis reduced progeny release in vitro , decreased Chlamydia burden in low genital tract of mice, and showed a trend toward attenuation of pathology.

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