The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy.

However, due to the relatively small effects, high variability between experiments, and possible confounding effect of a general stress response induced by the transfection procedure, the difference between active and inactive enzymes did not reach statistical significance.

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Quantification of the number of red dots in BPLF1- or BPLF1 C61A -positive and -negative cells from the same transfection revealed highly significant suppression of reticulophagy in cells expressing the catalytically active vDUB ( Figure 8C ).

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