The effect of enteral nutrition strategy and non-invasive ventilation on diarrhea and nutritional goals in the critically ill: A protocol for a multicentre retrospective cohort study (ENND GOALS).

PLoS One · 2025 · PMC12013913 · PMID 40261868

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0.1800

closest p · 3.6× alpha

0.1800

boldest claim

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showed a trendp = 0.18not close (p > 0.1)

The American Society of Parenteral and Enteral Nutrition (ASPEN) recommends avoidance of IEN in high-risk patients based on 2 small RCTs which showed a trend towards higher mortality with IEN (13.9% IEN vs 7.4% CEN; p = 0.18) and increased risk of ventilator association pneumonia with IEN (49.3% IEN vs 30.9% CEN, p=0.02) [ 1 , 7 , 8 ].

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