The effect of exercise therapy on pain, fatigue, bone function and inflammatory biomarkers individuals with rheumatoid arthritis and knee osteoarthritis: a meta-research review of randomized controlled trials.

Effect of exercise on inflammatory biomarkers The effect of exercise on CRP (ES = −0.52, 95% CI: −1.23, 0.18; P = 0.147; I 2 = 35.9%, P = 0.212), IL-6 (ES = −0.55, 95% CI: −1.48, 0.37; P = 0.244), and TNF-α (ES = −0.59, 95% CI: −1.24, 0.06; P = 0.073) levels did not reach statistical significance ( Figure 5B ).

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