Barely Significant
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The microbiome-derived metabolite trimethylamine N-oxide is associated with chronic kidney disease risk.

Appl Microbiol Biotechnol · 2025 · PMC12014799 · PMID 40261397

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a significant trendno p-value reported
The tertile 3 level of TMAO is associated with 1.123 times of increased risk of CKD, compared with the tertile 1, and a significant trend of increasing risk of CKD along with increasing TMAO level has been observed.

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