Barely Significant
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ACE inhibitory casein peptide lowers blood pressure and reshapes gut microbiota in a randomized double blind placebo controlled trial.

Sci Rep · 2025 · PMC12015250 · PMID 40263513

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a decreasing trendno p-value reported
In Supplementary Table S5, over the 8-week intervention, the endothelin-1 levels in both HCP and placebo groups exhibited a decreasing trend without statistically significant.

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In the HCP, simpson, Chao1 and ACE indices all showed increasing trends, but did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.