The percentage of free cortisol (FC) relative to total cortisol (TC), as measured by the AUC, was lower in subjects with obesity, though this difference did not reach statistical significance ( p = 0.077).
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Cortisol Secretion in Obesity Revisited: Lower Basal Serum and Salivary Cortisol with Diminished Cortisol Response to the Low Dose ACTH Challenge.
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0.0770
0.0770