Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance.

Analysis of splenic macrophages, identified as MHC class II + F4/80 + cells from a CD11b + origin 22 ( Figure 3 I), revealed a strong trend for a reduction in this population ( Figure 3 J) and that these splenic macrophages all had significantly reduced levels of CD40 ( Figure 3 K), PD-L1 ( Figure 3 L), CD86 ( Figure 3 M), and MHC class II ( Figure 3 N).

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In this setting, co-blockade of IL-27 and IFNγ resulted in a highly significant reduction in Tr1 cell frequency ( Figure 5 M), and analysis showed that this effect appeared to be additive when visualizing αIL-27 and αIFNγ treatment as factored variables ( Figure 5 N).

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