Predictive significance of <sup>18</sup>F-FDG PET/CT metabolic parameters for the expression level of HER2 in gastric cancer.

Lastly, In the Highly and Moderately differentiated group, MTV showed a trend toward negative association with HER2 positivity (β=-0.1345, P=0.0576), whereas TLG had no predictive value (P=0.5853).For Low polarization tumors, neither MTV nor TLG reached statistical significance (both P>0.25), likely due to limited sample size (n=23) ( Table 5 ). 4.

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In the histological grade group, the marginal significance of MTV in High/Middle grade tumors suggests potential utility as a non-invasive biomarker, but further validation in larger cohorts is warranted.

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