NMN reverses D-galactose-induced neurodegeneration and enhances the intestinal barrier of mice by activating the Sirt1 pathway.

Administration of NMN at 250 mg/kg and 500 mg/kg increased the number of target quadrant crossings ( Figure 2C ) and residence time in the target quadrant ( Figure 2D ), suggesting an improvement in spatial memory, although these differences did not reach statistical significance.

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