Midbrain and pallidal iron changes identify patients with REM sleep behaviour disorder and Parkinson's disease.

Dunn’s multiple comparison test revealed higher mean susceptibility in PD versus HC ( z = 3.17, p = 0.002), with the difference between the iRBD and PD trending toward significance ( z = 1.74, p = 0.08), suggesting iron elevation in the right VTA of PD patients (Fig. 3 ).

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There was a significant trend of decreasing QSM values in GPe and GPi across iRBD, PD non-RBD, and PD-RBD patients, which seems related to increasing motor severity measured with MDS-UPDRS-III (Supplementary Fig. 1 ).

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