Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial.

Crit Care · 2025 · PMC12020157 · PMID 40269974

Europe PMC DOI

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did not reach statistical significanceP = 0.30not close (p > 0.1)

Primary outcome The average post-baseline patient SOFA score on day 2 to 5 was slightly lower in the vitamin C group: 1.98 (95% CI 1.69 to 2.32) vs 2.19 (95% CI 1.87 to 2.56) in the placebo group but did not reach statistical significance ( P = 0.30).

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