Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma.

Importantly, although there was a positive correlation between MYC mRNA levels and nucleolar size, which did not reach statistical significance, BCL-2 mRNA levels were negatively correlated to nucleolar area values irrespective of MYC levels: in fact, while increased BCL-2 mRNA levels were associated with decreased nucleolar size in both MYC -low and MYC -high subgroups, on the contrary, MYC mRNA levels did not correlate with nucleolar area when categorizing based on BCL-2 mRNA expression levels ( Figures 5 F and S6 E).

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