Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells.

Islets isolated from high cholesterol-fed mice displayed a near-significant increase in cholesterol ( Figure 1—figure supplement 1A ) accompanied by decreased exendin-4-induced cAMP responses ex vivo ( Figure 1—figure supplement 1B ), highlighting the negative impact of even mild increases in cholesterol on GLP-1R signalling.

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