Characterization of Lipophilicity and Blood Partitioning of Pyrrolizidine Alkaloids and Their N-Oxides In Vitro and In Silico for Toxicokinetic Modeling.

Planta Med · 2025 · PMC12021451 · PMID 39848281

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closest p

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showed a trendno p-value reported

This is in opposition to the N -oxidation of pyridines, aromatic weak bases with a chemical structure related to PAs, which was reported to increase hydrophilicity 24 . Log P values calculated using in silico methodologies showed a trend for overprediction for PAs and PANOs.

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