A CRISPR homing screen finds a chloroquine resistance transporter-like protein of the Plasmodium oocyst essential for mosquito transmission of malaria.

Nat Commun · 2025 · PMC12022033 · PMID 40274854

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did not reach statistical significanceno p-value reported

For pantothenate kinase 2 ( pank2 ), a complete loss of oocysts was expected 22 , but the homing effect was smaller than for other known oocyst genes (1.7-fold) and did not reach statistical significance.

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