Evolution of Zika virus in <i>Rag1</i>-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitness.

The serum titres at euthanasia did not show a clear trend with passage number ( Fig. 1d ), with arboviral viremias in Rag1 -/- mice tending towards a steady state level after 1–2 weeks ( Poo et al. 2014 ).

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This is consistent with a marginal trend towards less CPE for ZIKV-N154D vs.

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