Metagenomic Microbial Signatures for Noninvasive Detection of Pancreatic Cancer.

Biomedicines · 2025 · PMC12025148 · PMID 40299688

Europe PMC DOI

hedged sentence

0.3300

closest p · 6.6× alpha

0.3300

boldest claim

The sentences

did not reach statistical significancep = 0.33not close (p > 0.1)

In younger individuals (<55 years), the integration of microbial signatures with CA19-9 yielded modest enhancements in diagnostic performance (model 1 + CA19-9: AUC = 0.962; model 2 + CA19-9: AUC = 0.913) compared to CA19-9 alone (AUC = 0.782), although these improvements did not reach statistical significance ( p = 0.33 and 0.52).

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