Targeting Insulin Resistance and Liver Fibrosis: CKD Screening Priorities in MASLD.

Biomedicines · 2025 · PMC12025161 · PMID 40299399

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

borderline significancep = 0.09so close (0.05 < p ≤ 0.1)

Although the interaction between MASLD and insulin resistance showed only borderline significance after multiple testing correction (adjusted p = 0.09), the direction and magnitude of the effect (OR = 2.02) align with mechanistic hypotheses positing insulin resistance as a shared driver of both MASLD progression and renal injury.

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did not reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

Our exploratory analysis suggests a potential modifying role of insulin resistance in the MASLD–CKD association, though this finding did not reach statistical significance after adjustment for multiple comparisons (adjusted p = 0.09). 3.5.

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