Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations.

However, this difference did not reach statistical significance ( p = 0.101).

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Unlike the findings for TGF-beta and WNT pathway alterations, the survival analysis for the EOCRC H/L patients based on RTK/RAS pathway alterations ( Figure 1 ) indicated a possible trend toward worse survival outcomes in those with RTK/RAS mutations ( p = 0.87).

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While the RTK/RAS-altered group (red curve) displayed a slight trend toward reduced survival compared to those without alterations (blue curve), the overlapping curves and wide confidence intervals indicated substantial variability in survival estimates.

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