Disruption of Man-6-P-Dependent Sorting to Lysosomes Confers IGF1R-Mediated Apoptosis Resistance.

Since these drugs are known to induce apoptosis, we next measured the specific activity of caspases 3/7, proteases that are activated in both intrinsic and extrinsic apoptosis pathways, and found that it increased to a lesser extent in GNPTAB KO HeLa cells compared to control cells after the indicated treatments ( Figure 1 B, p < 0.01, except for paclitaxel, for which the difference did not reach statistical significance).

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