GWAS by Subtraction to Disentangle RBD Genetic Background from α-Synucleinopathies.

According to authors’ recommendations, we removed SNPs with highly significant Q-statistics pvalues, since it indicates that they are likely to mediate their effects trough single traits rather than the common factor, which instead was the focus of the F2 mGWAS. 4.4.

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While MR-Egger and mode-based estimators did not reach statistical significance, their effect sizes were consistent with a negative association ( Supplementary Table S4 and Supplementary File SF7 ).

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