Proenkephalin 119-159 in Heart Failure: From Pathophysiology to Clinical Implications.

J Clin Med · 2025 · PMC12027756 · PMID 40283487

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failed to reach statistical significanceno p-value reported

further confirmed the role of PENK 119–159 as a robust predictor of cardiorenal syndrome type 1, with an AUC of 0.9, while the reference biomarker NGAL failed to reach statistical significance [ 76 ].

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