Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling in the ES-2 Ovarian Carcinoma Cell Line, Influencing Cell Proliferation, Quiescence, and Chemoresistance in a Cell-of-Origin-Specific Manner.

Under normoxia, cells stimulated with Late-cfDNA-NoGluc variant showed significantly increased levels of lipids peroxides compared to the variant Early-cfDNA-NoGluc, which was the only variant that showed a trend of decreasing lipid peroxidation levels upon cisplatin treatment ( Figure 3 K).

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