Predictive Lung- and Spleen-Targeted mRNA Delivery with Biodegradable Ionizable Lipids in Four-Component LNPs.

Notably, a clear trend was observed based on the zeta potential, with LNPs exhibiting selectivity for splenic tissue demonstrating a negative zeta potential (range −19 to −9.7 mV; Figure 3 D and Table S2 ), whereas those preferentially targeting pulmonary tissue displayed a slightly positive surface charge (range 0.95 to 3.5 mV; Figure 3 D and Table S2 ).

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