Maternal cell-free DNA in early pregnancy for preeclampsia screening: a systematic review.

Arch Gynecol Obstet · 2025 · PMC12033209 · PMID 39870917

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

However, based on the reported confidence intervals, the incremental increase in the AUC for total cfDNA plus PAPP-A compared with PAPP-A alone did not reach statistical significance ( P = 0.06).

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