Barely Significant
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Plasma Exchange vs. Immunoadsorption: Effects on Immunological Markers and Predictive Value in Steroid-Refractory MS Attacks.

Mult Scler J Exp Transl Clin · 2025 · PMC12033861 · PMID 40292037

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hedged sentence
0.1080
closest p · 2.2× alpha
0.1080
boldest claim

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did not reach statistical significancep = 0.108not close (p > 0.1)
The comparison of the percentage difference between preprocedural and postprocedural serum concentrations did not reach statistical significance (PLEX: median −34.74 (IQR −45.15 – + 1.25) %; IA: median −7.95 (IQR −33.03 – + 18.56) %, p = 0.108). λ-FLC were equally reduced in both treatment groups post-intervention (PRE PLEX: median 7.70 (IQR 5.20–11.85) mg/l, POST PLEX 3.60 (IQR 3.50–4.05) mg/l; PRE – POST PLEX: p < 0.001; PRE IA: median 6.60 (IQR 5.95–9.35) mg/l, POST IA: median 3.90 (IQR 3.55–4.65) mg/l; PRE – POST IA: p < 0.001).

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