Targeting polyunsaturated fatty acids desaturase FADS1 inhibits renal cancer growth via ATF3-mediated ER stress response.

Also, the ATF3 levels in the xenograft tumors developed from the FADS1-KD cells are not significantly different from that of the control tumors, though an apparent trend can be observed (5 out of 7 FADS1-KD tumors demonstrated an elevated level of ATF3), which may be largely due to the potential sex-specific differences, tumor-specific extent of ER stress, and the small sample size.

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Our data showed a trend of increased ATF3 expression in the tumors derived from sh-FADS1 cells (3 out of samples in females and 2 out 3 samples in males), though there was no statistical significance, possibly due to the small sample size ( Fig. 7F – G ).

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