Microstructural assessment of the locus coeruleus-entorhinal cortex pathway and association with ATN markers in cognitive impairment.

Alzheimers Dement · 2025 · PMC12035542 · PMID 40289861

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

showed a trendp = 0.075so close (0.05 < p ≤ 0.1)

Statistical comparisons showed that A and T biomarkers discriminated CI from CU ( p < 0.001), while N showed a trend for significance ( p = 0.075).

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marginally significantno p-value reported

While the factor contributing most strongly in the model was tau, LC–EC MD was still marginally significant, supporting the added value of LC–EC diffusivity in predicting CI.

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