Direct Oral Anticoagulants Are Comparable to Low Molecular Weight Heparin at Sustaining the Circulating Extracellular Vesicle and Inflammatory Profiles of Cancer Associated Thrombosis Patients: An Observational Pilot Study.

A slight trend in lower circulating EVs in the DOAC arm was observed in both the small and large EVs; however, significance was not reached (Figure 2A : small EVs; p = 0.4577, Figure 2C : large EVs; p = 0.4574).

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Moreover, Hepatocyte Growth Factor (HGF) levels exhibited the largest reduction in the DOAC compared to LMWH treatment of all the cytokines quantified, approaching significance, and demonstrated a moderate and statistically significant correlation with plasma levels of citrullinated Histone H3 (CitH3, Figure S1C ).

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