Cgref1 is a CREB-H-regulated hepatokine that promotes hepatic <i>de novo</i> lipogenesis by mediating epididymal fat insulin resistance.

Int J Biol Sci · 2025 · PMC12035884 · PMID 40303310

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only marginally significantno p-value reported

Indeed, glucose uptake at eWAT was suppressed, although only marginally significant (Figure 4 B).

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Cgref1 is a CREB-H-regulated hepatokine that promotes hepatic &lt;i&gt;de novo&lt;/i&gt; lipogenesis by mediating epididymal fat insulin resistance.

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Cgref1 is a CREB-H-regulated hepatokine that promotes hepatic <i>de novo</i> lipogenesis by mediating epididymal fat insulin resistance.