Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis.

The FA values in the hippocampal brain region were reduced in HFD-induced diabetic mice compared to the Chow-control group, indicating microstructural damage in the hippocampal brain region of diabetic mice, but this difference did not reach statistical significance ( Figure 2 J-K ).

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