Prenatal methadone exposure produces functional and molecular alterations in the basolateral amygdala and decreased voluntary ethanol intake in female, but not male offspring.

Front Behav Neurosci · 2025 · PMC12037550 · PMID 40302935

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a strong trendp = 0.054so close (0.05 < p ≤ 0.1)

Interestingly, in females, a 2-way ANOVA revealed a main effect of exposure ( Figure 2B : F (1, 16) = 8.198, p < 0.05) and an exposure × week interaction ( F (2, 32) = 5.07, p < 0.05), with a strong trend toward a main effect of week ( F (2, 32) = 3.208, p = 0.054).

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