Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population.

Clin Transl Sci · 2025 · PMC12038368 · PMID 40297930

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

trending towards significancep = 0.07so close (0.05 < p ≤ 0.1)

Moreover, patients with decreased OATP1B1 function, including those with * 1b/ * 5 and * 1b/ * 15 , showed consistent increases in simvastatin acid concentrations compared to patients with normal OATP1B1 function, with a p value trending towards significance ( p = 0.07).

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