Opioid Therapy in Chronic Pain: Assessment of Clinical Outcomes and Relationships With Endocrine Biomarkers.

Eur J Pain · 2025 · PMC12038877 · PMID 40298042

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slightly significantno p-value reported

Notably, the significant natural indirect effect of TT on anxiety in men was slightly significant, suggesting that some effects might arise from the direct opioids effect or a combined treatment effect including mediators.

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