Liver transplant-facilitated CD161<sup>+</sup>Vα7.2<sup>+</sup> MAIT cell recovery demonstrates clinical benefits in hepatic failure patients.

Through analysis of bulk RNA sequencing dataset from sorted MAIT cells, we observed that cMAIT-LF and hMAIT-LF from LF patients showed a trend toward upregulating SELL (CD62L) and CCR7 transcripts that reflected the enhanced capacity of recirculation via lymph, while downregulating CXCR6 , CCR6 , CXCR3 , and CRTAM that are tissue homing receptors and retention molecules 34 (Fig. 4C , Supplementary Fig. 9A, B , and Supplementary Data 5.1 ).

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