Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport.

NPJ Vaccines · 2025 · PMC12041602 · PMID 40301369

Europe PMC DOI

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0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

failed to reach statistical significancep = 0.067so close (0.05 < p ≤ 0.1)

Neutralization titers in BALB/c mice receiving 1% RNAx at the 0.05 μg total dose increased slightly but failed to reach statistical significance ( p = 0.067, Kruskal-Wallis test with Dunn’s multiple comparisons) (Supplementary Fig. 8D ).

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