Familial Renal Glucosuria and Potential Pharmacogenetic Impact on Sodium-Glucose Cotransporter-2 Inhibitors.

Of the three polymorphic missense variants, two were significantly associated with renal glucosuria and passed an experiment-wise Bonferroni threshold ( P < 0.00625) (p.[Val470Ala], FIRTH P = 2.46E-5; p.[Ile433Val], FIRTH P = 0.00223), whereas a third variant marginally approached significance in PMRP (p.[Asn654Ser], FIRTH P = 0.0877) (Figure 1 and Table 3 ).

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