Hepatocyte TM4SF5-mediated cytosolic NCOA3 stabilization and macropinocytosis support albumin uptake and bioenergetics for hepatocellular carcinoma progression.

Exp Mol Med · 2025 · PMC12046047 · PMID 40186033

Europe PMC DOI

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0.0925

closest p · 1.8× alpha

0.0925

boldest claim

The sentences

showed a trendP = 0.0925so close (0.05 < p ≤ 0.1)

Meanwhile, among patients with [ALB] serum >3.77 g/dl, the NCOA3 high or TM4SF5 high /NCOA3 high groups showed significantly poorer clinical outcomes compared with those of the TM4SF5 low /COA3 low group, and the TM4SF5 high group showed a trend toward a poor clinical outcome (nonsignificant, P = 0.0925; Fig. 8c ).

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