Interestingly, we found that LOY was only associated with higher all-cause mortality (HR 1.81, 95% CI 1.16–2.83) in patients with myocardial fibrosis wGRS > 0, although the interaction term between LOY and fibrosis wGRS did not reach statistical significance ( P interaction = .229; Figure 5A ; Supplementary data online , Table S16 ).
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