A Bifunctional Antibody Targeting PD-1 and TGF-β Signaling Has Antitumor Activity in Combination with Radiotherapy and Attenuates Radiation-Induced Lung Injury.

Cancer Immunol Res · 2025 · PMC12046334 · PMID 39878763

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The PACIFIC study ( 12 ) also showed a trend toward a higher incidence of pneumonitis with sequential durvalumab (an anti–PD-L1) versus placebo after chemoradiotherapy (33.9% vs. 24.8%).

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