a strong trend toward increased Gper1 levels in CRC cancer tissue compared to adjacent tissue was reported by Gilligan et al ( 56 ) while down-regulated expression of Gper1 was reported by Liu et al ( 51 ).
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Differences in the role of Gper1 in colorectal cancer progression depending on sex.
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When the cohort was split according to nodal involvement only (without considering TNM staging as a whole) the sex-dependent difference in gper1 expression became even more pronounced, and there was a highly significant increase in gper1 expression in cancer tissue compared to adjacent tissue in males without nodal involvement ( Fig. 4A ).