Valve thrombosis and antithrombotic therapy after bioprosthetic mitral valve replacement: a systematic review and meta-analysis.

Our main findings are as follows: (i) bMVT occurred with an overall incidence of 5.05 events per 100-patient-years; (ii) bMVT events were numerically more common in the early (≤90 days) compared to late (>90 days) period after valve replacement but the rates were statistically comparable; (iii) the incidence of bMVT was higher in transcatheter compared to surgical bioprostheses but the comparison did not reach statistical significance; (iv) patients taking oral anticoagulation had a significantly lower incidence of bMVT compared to patients without; and (iv) VKA were associated with a significantly lower rate of bVMT than DOACs.

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