Notably, a subgroup analysis showed a trend toward benefit with the higher dose, raising concerns about the adequacy of the colchicine dose used in the trial. 4 In addition to timing and dosing, the concomitant therapy administered across trials may explain the conflicting results of randomized trials on CAD patients.
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CLEAR results, cloudy impact: colchicine's neutral role in ST-segment elevation myocardial infarction.
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