Comparative effectiveness of monotherapy vs. combination therapy for postoperative central nervous system infections in neurosurgical patients: a retrospective cohort study.

BMC Infect Dis · 2025 · PMC12046949 · PMID 40316931

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0650

boldest claim

The sentences

highly significantp < 0.001actually significant

This association remained highly significant in the multivariate model, with females being 2.42 times more likely to be assigned to combination therapy (OR: 2.417, 95% CI: 1.445–4.126; p < 0.001).

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a trend toward significancep = 0.058so close (0.05 < p ≤ 0.1)

Ethnicity showed a trend toward significance before matching ( p = 0.058) but no significant differences after matching ( p = 0.938).

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did not reach statistical significancep = 0.065so close (0.05 < p ≤ 0.1)

Additionally, the Hui ethnic group showed a trend toward a lower likelihood of receiving combination therapy, although this did not reach statistical significance in the multivariate analysis (OR: 0.356, 95% CI: 0.106–0.986; p = 0.065).

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