Epigenetic age acceleration is related to cognitive decline in the elderly: Results of the Austrian Stroke Prevention Study.

Even after correcting for multiple testing, these effects were highly significant in the domains of memory and speed as well as on global cognition.

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These findings suggest that the PC versions of these DNAmAge algorithms capture similar epigenetic variability, which is also reflected in the increased number of nominally significant associations with declines in memory, speed, and global cognition with the PC‐trained versions (Fig. 4 , Table S4 ).

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