Plasma Trough Concentrations of Beta-Lactam Antibiotics in the Early Phase of Septic Shock.

Acta Anaesthesiol Scand · 2025 · PMC12047412 · PMID 40318028

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

borderline significancep = 0.051so close (0.05 < p ≤ 0.1)

Borderline significance was noted for the association between elevated creatinine ( p = 0.051) and CCI ( p = 0.062) with100% f T > MIC, while no associations were found for sex or lactate.

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showed a trendno p-value reported

The majority showed a trend toward decreasing concentrations despite an extra dose, suggesting increased volume of distribution and possibly, in some cases, increased renal elimination.

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