Lactated Ringer's or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension.

Crit Care Med · 2025 · PMC12047640 · PMID 39969246

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did not reach statistical significanceno p-value reported

In our sensitivity analysis, omitting sex, the Charlson Comorbidity Index, the Glasgow Coma Scale, blood pressure and the amount of lactated Ringer’s solution and 0.9% saline after randomization, and adding chronic kidney disease as an independent covariate (outside of the Charlson Comorbidity Index) yielded similar estimates but did not reach statistical significance.

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