Systemic IGF-1 administration prevents traumatic brain injury induced gut permeability, dysmorphia, dysbiosis, and the increased number of immature dentate granule cells.

Acta Neuropathol Commun · 2025 · PMC12049052 · PMID 40319295

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0.0510

closest p · 1.0× alpha

0.0510

boldest claim

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a strong trendp = 0.051so close (0.05 < p ≤ 0.1)

Consistent with previous studies indicating that FPI induces early increases in adult hippocampal neurogenesis [ 74 , 85 ], the results show that FPI resulted in a strong trend towards an increased number of DCX-labeled immature neurons in the dentate gyrus ( p = 0.051, NS ).

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