Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma.

Cancer Metastasis Rev · 2025 · PMC12049340 · PMID 40317360

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did not reach statistical significanceno p-value reported

Given that peritoneal metastasis frequently correlates with diffuse-type histology, it is notable that in both the SPOTLIGHT and GLOW trials, the OS benefit for patients with diffuse gastric cancer did not reach statistical significance in the prespecified subgroup analyses (SPOTLIGHT HR 0.76 [0.51–1.13]; GLOW HR 0.73 [0.49–1.07]).

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